In 2015, a seminal Lancet report suggested that “anthropogenic climate change threatens to undermine the past 50 years of gains in public health” In the summer of 2016, a 12-year-old boy died after being exposed to anthrax spores from a frozen reindeer carcass that had been uncovered by thawing permafrost The climate crisis, habitat destruction, and our globalised food production systems all increase uncertainty when considering the future of disease. How we prepare for the changing disease landscape will therefore be decided by how we manage these causes.